Advanced molecular brain tumour classification with epigenetic profiling

This one-day workshop will provide a multifaceted view of epigenetic profiling in adult and paediatric brain tumour diagnostics. The workshop will convey the biological principles of epigenetics in health and disease with a focus on brain tumours and explain how methylation profiles are detected with current array technologies. The application of machine learning and the development of algorithms used for the classification of brain tumours will be presented. The introduction of methylation profiling and algorithmic classification into CNS tumour diagnostics in the UK will be complemented with examples of how such an approach can be applied to improve precision in paediatric and adult CNS tumour diagnostics. Also, the limitations and pitfalls of this technology will be addressed.